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Article

Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin.

Biochemical and biophysical research communications - 11 Sept 2009

Kabuta Tomohiro, Kinugawa Aiko, Tsuchiya Yukihiro, Kabuta Chihana, Setsuie Rieko, Tateno Minako, Araki Toshiyuki, Wada Keiji

Abstract excerpt

Mutations in the Cu,Zn-superoxide dismutase (SOD1) gene cause 20-25% of familial amyotrophic lateral sclerosis (ALS). Mutant SOD1 causes motor neuron degeneration through toxic gain-of-function(s). However, the direct molecular targets of mutant SOD1, underlying its toxicity, are not fully understood. In this study, we found that alpha/beta-tubulin is one of the major mutant SOD1-interacting proteins, but that...

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Identifiers

PMID: 19576169
DOI: 10.1016/j.bbrc.2009.06.138

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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