Article
[Cytogenetic and molecular basis of multiple myeloma].
Nihon rinsho. Japanese journal of clinical medicine - 1 Dec 2007
Taniwaki Masafumi, Matsumoto Yosuke
Abstract excerpt
Multiple myeloma(MM) originating from plasma cells is characterized by complex chromosomal aberrations. The most prominent chromosomal abnormalities of MM are aneuploidy and translocations affecting the immunoglobulin heavy chain locus on chromosome 14q32. Additionally, a variety of genetic aberrations such as ras mutations have been found in MM. Because these chromosomal and genetic abnormalities are closely...
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