Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.

Pharmacogenetics - 1 Oct 2004

Wojnowski Leszek, Turner Paul C, Pedersen Bonnie, Hustert Elisabeth, Brockmöller Jürgen, Mendy Maimuna, Whittle Hilton C, Kirk Greg, Wild Christopher P

Abstract excerpt

OBJECTIVES: Major risk factors for hepatocellular carcinoma (HCC) are hepatitis viruses and exposure to aflatoxins, including aflatoxin B1 (AFB1). The mutagenic effect of AFB1 results from hepatic bioactivation to AFB1-exo-8,9-epoxide. This is in part catalysed by CYP3A5, an enzyme expressed polymorphically. We investigated the role of CYP3A5 polymorphisms in the formation of AFB1-exo-8,9-epoxide in The Gambia, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aflatoxin B1
Share to Aflatoxins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Albumins

Share to Carcinoma, Hepatocellular

Share to Cytochrome P-450 CYP3A

Share to Cytochrome P-450 Enzyme System

Share to Gambia

Share to Mutagens

Source

Identifiers

PMID: 15454734
DOI: 10.1097/00008571-200410000-00007

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.PMID 15454734Read ↗

Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia.Semantic proximity Read ↗

Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West Africa.Semantic proximity Read ↗

When less is more: The association between the expression of polymorphic CYPs and AFB1-induced HCC.Semantic proximity Read ↗

CYP3A5 phenotype-genotype correlations in a British population.Semantic proximity Read ↗

Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in relation to HBV infection and hepatocellular carcinoma in The Gambia and Thailand.Semantic proximity Read ↗

TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia.Semantic proximity Read ↗

Hepatitis B virus preS2Δ38–55 variants: A newly identified risk factor for hepatocellular carcinomaSemantic proximity Read ↗

The genetic determinants of the CYP3A5 polymorphism.Semantic proximity Read ↗

Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity.Semantic proximity Read ↗

Aflatoxin, liver enzymes, and hepatitis B virus infection in Gambian children.Semantic proximity Read ↗

Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma.Semantic proximity Read ↗

Hepatocellular carcinoma: from gene to public health.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.