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Article

Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans.

Journal of cell science - 15 Oct 2004

Moribe Hiroki, Yochem John, Yamada Hiromi, Tabuse Yo, Fujimoto Toyoshi, Mekada Eisuke

Abstract excerpt

Epidermal integrity is essential for animal development and survival. Here, we demonstrate that TSP-15, a member of the tetraspanin protein family, is required for epithelial membrane integrity in Caenorhabditis elegans. Reduction of tsp-15 function by mutation or by RNA interference elicits abnormalities of the hypodermis, including dissociation of the cuticle and degeneration of the hypodermis. Lethality during...

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PMID: 15454573
DOI: 10.1242/jcs.01403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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