Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants.

Abstract excerpt

Transporting epithelia provide a protective barrier against pathogenic insults while allowing the controlled exchange of ions, solutes and water with the external environment. In invertebrates, these functions depend on formation and maintenance of 'tight' septate junctions (SJs). However, the mechanism by which SJs affect transport competence and tissue homeostasis, and how these are modulated by ageing, remain...

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