Dose-sensitive autosomal modifiers identify candidate genes for tissue autonomous and tissue nonautonomous regulation by the Drosophila nuclear zinc-finger protein, hindsight.

doi:10.1534/genetics.104.031344

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Article

Dose-sensitive autosomal modifiers identify candidate genes for tissue autonomous and tissue nonautonomous regulation by the Drosophila nuclear zinc-finger protein, hindsight.

Genetics - 1 Sept 2004

Wilk Ronit, Pickup Amanda T, Hamilton Jill K, Reed Bruce H, Lipshitz Howard D

Abstract excerpt

The nuclear zinc-finger protein encoded by the hindsight (hnt) locus regulates several cellular processes in Drosophila epithelia, including the Jun N-terminal kinase (JNK) signaling pathway and actin polymerization. Defects in these molecular pathways may underlie the abnormal cellular interactions, loss of epithelial integrity, and apoptosis that occurs in hnt mutants, in turn causing failure of morphogenetic...

Topics

Actins
Animals
Chromosome Mapping
Chromosomes
Collagen Type IV
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Eye
Gene Expression Regulation, Developmental
Genes, Regulator
JNK Mitogen-Activated Protein Kinases
Laminin

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MAP Kinase Kinase 4

Mitogen-Activated Protein Kinase Kinases

Mutation

Nuclear Proteins

Phenotype

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Identifiers

PMID: 15454543
DOI: 10.1534/genetics.104.031344
PMCID: PMC1448082

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