Article
Analysis of the sequence and phenotype of Drosophila Sex combs reduced alleles reveals potential functions of conserved protein motifs of the Sex combs reduced protein.
Genetics - 1 May 2009
Sivanantharajah Lovesha, Percival-Smith Anthony
Abstract excerpt
The Drosophila Hox gene, Sex combs reduced (Scr), is required for patterning the larval and adult, labial and prothoracic segments. Fifteen Scr alleles were sequenced and the phenotypes analyzed in detail. Six null alleles were nonsense mutations (Scr(2), Scr(4), Scr(11), Scr(13), Scr(13A), and Scr(16)) and one was an intragenic deletion (Scr(17)). Five hypomorphic alleles were missense mutations (Scr(1), Scr(3),...
Topics
- Alleles
- Animals
- Blotting, Western
- Codon, Nonsense
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Larva
- Mutation, Missense