Article
Analysis of Deinococcus radiodurans's transcriptional response to ionizing radiation and desiccation reveals novel proteins that contribute to extreme radioresistance.
Genetics - 1 Sept 2004
Tanaka Masashi, Earl Ashlee M, Howell Heather A, Park Mie-Jung, Eisen Jonathan A, Peterson Scott N, Battista John R
Abstract excerpt
During the first hour after a sublethal dose of ionizing radiation, 72 genes were upregulated threefold or higher in D. radiodurans R1. Thirty-three of these loci were also among a set of 73 genes expressed in R1 cultures recovering from desiccation. The five transcripts most highly induced in response to each stress are the same and encode proteins of unknown function. The genes (ddrA, ddrB, ddrC, ddrD, and...
Topics
- Deinococcus
- Dose-Response Relationship, Radiation
- Epistasis, Genetic
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Mutation
- Oligonucleotide Array Sequence Analysis
- Radiation Tolerance
- Radiation, Ionizing