Article
Parkin transcript variants in rat and human brain.
Neurochemical research - 1 Sept 2004
Dagata Velia, Cavallaro Sebastiano
Abstract excerpt
Alternative splicing has an important role in expanding protein diversity. We have identified complementary DNA species from adult rat and fetal human brain encoding seven new splice variants of parkin, a gene mutated in autosomal recessive juvenile parkinsonism (ARJP). Alternative splicing affects almost all previously characterized exons, plus 3 new exons of 72, 156, and 180 nucleotides. This creates the...
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