Article
Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain.
BioMed research international - 1 Jan 2014
Scuderi Soraya, La Cognata Valentina, Drago Filippo, Cavallaro Sebastiano, D'Agata Velia
Abstract excerpt
Parkinson protein 2, E3 ubiquitin protein ligase (PARK2) gene mutations are the most frequent causes of autosomal recessive early onset Parkinson's disease and juvenile Parkinson disease. Parkin deficiency has also been linked to other human pathologies, for example, sporadic Parkinson disease, Alzheimer disease, autism, and cancer. PARK2 primary transcript undergoes an extensive alternative splicing, which...
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