Article
Identification and characterization of a novel endogenous murine parkin mutation.
Journal of neurochemistry - 1 Apr 2010
Ramsey Chenere P, Giasson Benoit I
Abstract excerpt
Various mutations in the PARK2 gene which encodes the protein, parkin, are causal of a disease entity-termed autosomal recessive juvenile parkinsonism. Parkin can function as an E3 ubiquitin-protein ligase, mediating the ubiquitination of specific targeted proteins and resulting in proteasomal de...
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