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Article

TetX Is a Flavin-dependent Monooxygenase Conferring Resistance to Tetracycline Antibiotics

28 Sept 2004

Abstract excerpt

The tetracycline antibiotics block microbial translation and constitute an important group of antimicrobial agents that find broad clinical utility. Resistance to this class of antibiotics is primarily the result of active efflux or ribosomal protection; however, a novel mechanism of resistance has been reported to be oxygen-dependent destruction of the drugs catalyzed by the enzyme TetX. Paradoxically, the tetX...

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Share to Antibiotic Resistance in Bacteria
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PMID: 15452119
DOI: 10.1074/jbc.m409573200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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