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Article

Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics

17 Dec 2009

Abstract excerpt

Carbapenems are a clinically important antibiotic family. More than 50 naturally occurring carbapenam/ems are known and are distinguished primarily by their C-2/C-6 side chains where many are only differentiated by the oxidation states of these substituents. With a limited palette of variations the carbapenem family comprises a natural combinatorial library, and C-2/C-6 oxidation is associated with increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20017478
DOI: 10.1021/ja907320n

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