Article
Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees.
Biological psychiatry - 1 Oct 2004
Washizuka Shinsuke, Iwamoto Kazuya, Kazuno An-A, Kakiuchi Chihiro, Mori Kanako, Kametani Mizue, Yamada Kazuo, Kunugi Hiroshi, Tajima Osamu, Akiyama Tsuyoshi, Nanko Shinichiro, Yoshikawa Takeo, Kato Tadafumi
Abstract excerpt
BACKGROUND: Linkage with 18p11 is one of the replicated findings in molecular genetics of bipolar disorder. Because mitochondrial dysfunction has been suggested in bipolar disorder, NDUFV2 at 18p11, encoding a subunit of the complex I, reduced nicotinamide adenine dinucleotide (NADH)ubiquinone oxidoreductase, is a candidate gene for this disorder. We previously reported that a polymorphism in the upstream region...
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