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Article

The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification.

The Journal of biological chemistry - 3 Dec 2004

Chang Wing Y, Bryce Dawn M, D'Souza Sudhir J A, Dagnino Lina

Abstract excerpt

The epidermis is a stratified epithelium constantly replenished through the ability of keratinocytes in its basal layer to proliferate and self-renew. The epidermis arises from a single-cell layer ectoderm during embryogenesis. Large proliferative capacity is central to ectodermal cell and basal keratinocyte function. DP-1, a heterodimeric partner of E2F transcription factors, is highly expressed in the ectoderm...

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Identifiers

PMID: 15448153
DOI: 10.1074/jbc.M408635200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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