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Article

Islet amyloid polypeptide gene: no evidence of abnormal promoter region in thirty-five type 2 diabetic patients.

Diabetes research and clinical practice - 1 Jan 1994

Tokuyama Y, Kanatsuka A, Suzuki Y, Yamaguchi T, Taira M, Makino H, Yoshida S

Abstract excerpt

Aberrant expression of the IAPP gene may be involved in the pathogenesis and islet amyloid formation of type 2 (non-insulin dependent) diabetes mellitus. We sequenced 536 basepairs in the 5'-upstream sequence of the gene of 35 Japanese with this disease and 3 patients with maturity-onset diabetes in the young. The sequences corresponding to both alleles of the gene were identical to one another and to the...

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Source

Identifiers

PMID: 8200302
DOI: 10.1016/0168-8227(94)90042-6

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Islet amyloid polypeptide gene: no evidence of abnormal promoter region in thirty-five type 2 diabetic patients.PMID 8200302Read ↗

Studies of variability in the islet amyloid polypeptide gene in relation to Type 2 diabetes.Semantic proximity Read ↗

Islet amyloid polypeptide (IAPP) gene analysis in a Japanese diabetic with marked islet amyloid deposition.Semantic proximity Read ↗

Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis.Semantic proximity Read ↗

Restriction fragment length polymorphisms near the islet amyloid polypeptide gene in Japanese subjects.Semantic proximity Read ↗

The islet amyloid polypeptide gene and non-insulin-dependent diabetes mellitus in south Indians.Semantic proximity Read ↗

Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study.Semantic proximity Read ↗

Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.Semantic proximity Read ↗

No evidence for mutations in a putative subunit of the beta-cell ATP-sensitive potassium channel (K-ATP channel) in Japanese NIDDM patients.Semantic proximity Read ↗

Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects.Semantic proximity Read ↗

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