Article
Islet amyloid polypeptide gene: no evidence of abnormal promoter region in thirty-five type 2 diabetic patients.
Diabetes research and clinical practice - 1 Jan 1994
Tokuyama Y, Kanatsuka A, Suzuki Y, Yamaguchi T, Taira M, Makino H, Yoshida S
Abstract excerpt
Aberrant expression of the IAPP gene may be involved in the pathogenesis and islet amyloid formation of type 2 (non-insulin dependent) diabetes mellitus. We sequenced 536 basepairs in the 5'-upstream sequence of the gene of 35 Japanese with this disease and 3 patients with maturity-onset diabetes...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Amyloid
- Base Sequence
- Blood Glucose
- DNA Primers
- Diabetes Mellitus, Type 2
- Diet, Diabetic
- Female
- Genetic Variation
- Humans
- Hypoglycemic Agents
- Insulin
- Islet Amyloid Polypeptide
- Male
- Middle Aged