Article
Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation.
Biochemistry - 3 Mar 1992
Veldscholte J, Berrevoets C A, Brinkmann A O, Grootegoed J A, Mulder E
Abstract excerpt
Previous studies from this laboratory have described that LNCaP prostate tumor cells contain an androgen receptor (AR) with a point mutation in the steroid-binding domain (codon 868, Thr to Ala). This defect leads to a change in specificity of the AR. Estrogens, progestagens, and some anti-androgens (e.g., cyproterone acetate, hydroxyflutamide, nilutamide) stimulate LNCaP cell growth rate through the AR. The...
Topics
- Androgen Antagonists
- Cell Division
- Cell Nucleus
- Chloramphenicol O-Acetyltransferase
- Gene Expression Regulation, Neoplastic
- HeLa Cells
- Heat-Shock Proteins
- Humans
- Male
- Mutation