Article
Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 1997
Tan J, Sharief Y, Hamil K G, Gregory C W, Zang D Y, Sar M, Gumerlock P H, deVere White R W, Pretlow T G, Harris S E, Wilson E M, Mohler J L, French F S
Abstract excerpt
An androgen receptor (AR) gene mutation identified in the androgen-dependent human prostate cancer xenograft, CWR22, changed codon 874 in the ligand-binding domain (exon H) from CAT for histidine to TAT for tyrosine and abolished a restriction site for the endonuclease SfaNI. SfaNI digestion of AR exon H DNA from normal but not from prostate cancer tissue indicated H874Y is a somatic mutation that occurred before...
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