Article
Effect of anti-estrogens on the androgen receptor activity and cell proliferation in prostate cancer cells.
Urological research - 1 Dec 2004
Kawashima Hidenori, Tanaka Tomoaki, Cheng Jed-Sian, Sugita Syozo, Ezaki Kazuyoshi, Kurisu Takeshi, Nakatani Tatsuya
Abstract excerpt
Although some anti-estrogens have been reported to inhibit the proliferation of prostate cancer cells, few studies on the mechanism by which they suppress the growth of prostate cancer have been reported. We investigated, for the first time, whether anti-estrogens modulate the transactivation activity of the androgen receptor (AR) in prostate cancer cells. In DU-145 cells transfected with AR, the transactivation...
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