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Article

A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2002

James Alaina J, Agoulnik Irina U, Harris Jonathan M, Buchanan Grant, Tilley Wayne D, Marcelli Marco, Lamb Dolores J, Weigel Nancy L

Abstract excerpt

Functional analysis of androgen receptor (AR) gene mutations isolated from prostate cancer has led to the identification of residues that play important roles in the structure and function of the receptor. Here we report the characteristics of a novel AR mutation A748T located in helix 5 of the ligand-binding domain, which was identified in metastatic prostate cancer. Despite a normal hormone-binding affinity,...

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Identifiers

PMID: 12456791
DOI: 10.1210/me.2001-0281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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