Article
The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
The Journal of steroid biochemistry and molecular biology - 1 Mar 1992
Veldscholte J, Berrevoets C A, Ris-Stalpers C, Kuiper G G, Jenster G, Trapman J, Brinkmann A O, Mulder E
Abstract excerpt
The human prostate tumor cell line LNCaP contains an abnormal androgen receptor system with broad steroid binding specificity. Progestagens, estradiol and several antiandrogens compete with androgens for binding to the androgen receptor in the cells to a higher extent than in other androgen sensi...
Topics
- Binding Sites
- Cell Division
- Chloramphenicol O-Acetyltransferase
- Estrogen Antagonists
- HeLa Cells
- Hormones
- Humans
- Male
- Mutation
- Prostatic Neoplasms
- Receptors, Androgen
- Steroids
- Transfection