Correlation between trans-stilbene oxide-glutathione conjugation activity and the deletion mutation in the glutathione S-transferase class mu gene detected by polymerase chain reaction.

doi:10.1016/0006-2952(92)90591-6

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Article

Correlation between trans-stilbene oxide-glutathione conjugation activity and the deletion mutation in the glutathione S-transferase class mu gene detected by polymerase chain reaction.

Biochemical pharmacology - 4 Feb 1992

Brockmöller J, Gross D, Kerb R, Drakoulis N, Roots I

Abstract excerpt

Glutathione S-transferase (GST) class Mu activity was determined in 145 unrelated hospital patients in Berlin by measuring their conjugation activity towards the specific substrate trans-stilbene oxide (TSO) with two substrate concentrations (50 and 250 microM) in homogenates prepared from lymphocytes. Eighty individuals (55.2%) had an activity lower than 10 pmol/min/10(6) lymphocytes and were classified as GST...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Berlin
Chromosome Deletion
Female
Germany
Glutathione
Glutathione Transferase
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Lung Neoplasms

Lymphocytes

Male

Middle Aged

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 1540219
DOI: 10.1016/0006-2952(92)90591-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1540219-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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