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Article

DOR-1, A novel CD10+ stromal cell line derived from progressive Langerhans cell histiocytosis of bone.

Pediatric blood & cancer - 1 Feb 2005

Gogusev Jean, Telvi Louise, Murakami Ichiro, Lepelletier Yves, Nezelof Christian, Stojkoski Alexandre, Glorion Christophe, Jaubert Francis

Abstract excerpt

BACKGROUND: Langerhans cell histiocytosis (LCH) is granulomatous proliferative disorder characterized by the presence of activated Langerhans cells admixed with macrophages, lymphocytes, and eosinophils. In an effort to obtain an LCH ex vivo model, we succeeded in establishing the DOR-1 cell line from an LCH lesion of bone in a 3-year-old girl. PROCEDURE: The DOR-1 cell line was established from a CD1a...

Topics

Animals
Bone Diseases
Cell Differentiation
Cell Division
Cell Line
Child, Preschool
Female
Genotype
Histiocytosis, Langerhans-Cell
Humans
Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization, Fluorescence

Mice

Mice, Nude

Neprilysin

Stromal Cells

Source

Identifiers

PMID: 15390308
DOI: 10.1002/pbc.20090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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