Article
[Bone and soft tissue Langerhans cell histiocytosis with multinucleated giant cells and BRAF V600E mutation].
Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia - 1 Jan 2000
Machado Isidro, Columbie Ariel, Nieto Morales Gema, Forteza-Suarez Mariuska, Renó Céspedes Jesús de Los Santos, Marhuenda Fluixa Ana, Llombart-Bosch Antonio
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a heterogeneous disease characterized by proliferation of Langerhans cells and BRAF mutation in almost half of the cases. Bone involvement is common but large soft tissue disease is uncommon. We report a pediatric patient with a large tumor mass involving the left iliac bone and the adjacent soft tissue. The computed tomography scan showed an osteolytic lesion with soft...
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