Cultured Reed-Sternberg cells HDLM-1 and KM-H2 can be induced to become histiocytelike cells. H-RS cells are not derived from lymphocytes.

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Article

Cultured Reed-Sternberg cells HDLM-1 and KM-H2 can be induced to become histiocytelike cells. H-RS cells are not derived from lymphocytes.

The American journal of pathology - 1 Aug 1990

Hsu S M, Xie S S, Hsu P L

Abstract excerpt

Two Hodgkin's Reed-Sternberg cell (H-RS) lines, HDLM-1 and KM-H2, have phenotypes and functional properties very similar to those of H-RS cells in tissues. These two types of cells were induced to differentiate with a combination of phorbol ester, retinoic acid, and extracellular matrix. The induced cells displayed the morphology of histiocytes or histiocytelike cells, with a small, round or oval, eccentric...

Topics

Adult
Antigens, Differentiation
Antigens, Neoplasm
Arachidonic Acids
Biological Factors
Cell Transformation, Neoplastic
Cytokines
Extracellular Matrix
Gene Rearrangement
Histiocytes
Hodgkin Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Ki-1 Antigen

Lymphocytes

Male

Phagocytosis

Phenotype

Tetradecanoylphorbol Acetate

Source

Open in PubMed Open full text

Identifiers

PMID: 2167011
PMCID: PMC1877620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2167011-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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