Article
Association of HER-2 polymorphism with Japanese sporadic prostate cancer susceptibility.
The Prostate - 1 Jan 2005
Yokomizo Akira, Koga Hirofumi, Kinukawa Naoko, Tsukamoto Taiji, Hirao Yoshihiko, Akaza Hideyuki, Mori Mitsuru, Naito Seiji
Abstract excerpt
BACKGROUND: Genetic polymorphisms may affect the development of prostate cancer (Pca). HER-2 is a proto-oncogene that has an important role in many human cancers, including Pca. To determine the association of the HER-2 gene with Japanese sporadic Pca, we analyzed the frequency of codon 655 (A/G, isoleucine, or valine) in case and control group. METHODS: We genotyped Ile 655 Val in Pca patients (n = 285) and in...
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