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Comparison of BRCA2 Single Nucleotide Variants Between Japanese Patients With Familial Prostate Cancer, Sporadic Prostate Cancer, and Benign Prostatic Hyperplasia.

Anticancer research - 1 May 2025

Aoki Masanori, Matsui Hiroshi, Kurihara Sota, Ohtake Nobuaki, Nakazawa Shun, Tsuji Yusuke, Fujizuka Yuji, Arai Seiji, Nomura Masashi, Sekine Yoshitaka, Koike Hidekazu, Suzuki Kazuhiro, Miyazawa Yoshiyuki

Abstract excerpt

BACKGROUND/AIM: A family history of prostate cancer is an established risk factor for its development. The BRCA2 gene frequently harbors pathogenic mutations in patients with prostate cancer. This study compared single nucleotide variants (SNVs) in BRCA2 among patients with familial prostate cancer, primarily treated at our institution. PATIENTS AND METHODS: SNVs in the BRCA2 gene were analyzed in 141 patients...

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Identifiers

PMID: 40295048
DOI: 10.21873/anticanres.17593

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BRCA2

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