Article
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2005
Wijsman Ellen M, Daw E Warwick, Yu Xuesong, Steinbart Ellen J, Nochlin David, Bird Thomas D, Schellenberg Gerard D
Abstract excerpt
Several kindreds of Volga German (VG) ancestry have a single PS2 mutation that causes an autosomal dominant form of Alzheimer's disease (AD). These families show a wide range in age-at-onset, which suggests the existence of modifying factors other than the PS2 mutation. To examine evidence for a genetic basis of variation in onset age, we performed a Bayesian oligogenic segregation and linkage analysis on nine VG...
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