APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome.

doi:10.1002/alz.71738

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2026

Groeneveld Joan, Perlaza Danna, Olivé Clàudia, Grangeon Lou, Tesi Niccolo, Nicolas Aude, Jiang Chenyang, de Rojas Itziar, Wallon David, Rousseau Stéphane, Rovira Marta, de Asúa Diego Real, Moldenhauer Fernando, Mu Ruihao, Cassinari Kévin, Zarea Aline, Escabias Joaquim Aumatell, Lambert Jean-Charles, Pijnenburg Yolande A L, Hulsman Marc, Vijverberg Everard G B, Levin Johannes, Jucker Mathias, McDade Eric, Fortea Juan, Holstege Henne, Duits Flora H, Vermunt Lisa, Patel Maulikkumar, Johnson Matthew, Renton Alan E, Goate Alison M, Cruchaga Carlos, Pottier Cyril, Fernandez Maria Victoria, Belbin Olivia, Nicolas Gael, Dols-Icardo Oriol, van der Lee Sven J

Abstract excerpt

INTRODUCTION: An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain unclear. We investigated whether sporadic AD risk variants modify AAO. METHODS: We analyzed clinical and genetic data from 100 APP duplication (APPdup) carriers and 957 individuals with DS. Cox...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Age of Onset

Share to Alzheimer Disease

Share to Amyloid beta-Protein Precursor

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Down Syndrome

Share to Genetic Risk Score

Share to Heterozygote

Source

Open in PubMed Open full text

Identifiers

PMID: 42569826
DOI: 10.1002/alz.71738
PMCID: PMC13452017

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome.PMID 42569826Read ↗

Common genetic signatures of Alzheimer’s disease in Down SyndromeSemantic proximity Read ↗

The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset.Semantic proximity Read ↗

The extended tau haplotype and the age of onset of dementia in Down syndrome.Semantic proximity Read ↗

Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologySemantic proximity Read ↗

Alzheimer's disease in Down syndrome: An overlooked population for prevention trialsSemantic proximity Read ↗

Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein.Semantic proximity Read ↗

Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome.Semantic proximity Read ↗

The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodologySemantic proximity Read ↗

Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome.Semantic proximity Read ↗

From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approachSemantic proximity Read ↗

Genome-wide association analysis of age-at-onset in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.