Article
Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule.
Molecular microbiology - 1 Sept 2004
Mangold Monika, Siller Maria, Roppenser Bernhard, Vlaminckx Bart J M, Penfound Tom A, Klein Reinhard, Novak Rodger, Novick Richard P, Charpentier Emmanuelle
Abstract excerpt
The capacity of pathogens to cause disease depends strictly on the regulated expression of their virulence factors. In this study, we demonstrate that the untranslated mRNA of the recently described streptococcal pleiotropic effect locus (pel), which incidentally contains sagA, the structural gene for streptolysin S, is an effector of virulence factor expression in group A beta-haemolytic streptococci (GAS). Our...
Topics
- Bacterial Proteins
- Culture Media, Conditioned
- Gene Expression Regulation, Bacterial
- Phenotype
- RNA, Bacterial
- Streptococcus pyogenes
- Transcription, Genetic
- Untranslated Regions
- Virulence Factors