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Article

A Response Regulator That Represses Transcription of Several Virulence Operons in the Group A Streptococcus

15 Jun 1999

Abstract excerpt

A search for homologs of the Bacillus subtilis PhoP response regulator in the group A streptococcus (GAS) genome revealed three good candidates. Inactivation of one of these, recently identified as csrR (J. C. Levin and M. R. Wessels, Mol. Microbiol. 30:209-219, 1998), caused the strain to produce mucoid colonies and to increase transcription of hasA, the first gene in the operon for capsule synthesis. We report...

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PMID: 10368137
DOI: 10.1128/jb.181.12.3649-3657.1999

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