Coregulation of type 12 M protein and streptococcal C5a peptidase genes in group A streptococci: evidence for a virulence regulon controlled by the virR locus.

doi:10.1128/jb.172.2.696-700.1990

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Article

Coregulation of type 12 M protein and streptococcal C5a peptidase genes in group A streptococci: evidence for a virulence regulon controlled by the virR locus.

Journal of bacteriology - 1 Feb 1990

Simpson W J, LaPenta D, Chen C, Cleary P P

Abstract excerpt

Group A streptococci express at least two surface-associated virulence factors, the antiphagocytic M protein and the antichemotactic streptococcal C5a peptidase (SCP). Preliminary evidence suggested that the biosynthesis of these two proteins is coordinately controlled and subject to simultaneous phase variation. To explore this possibility further, a series of phase-switching and phase-locked M- variants were...

Topics

Adhesins, Bacterial
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins
Blotting, Northern
Blotting, Western
Carrier Proteins
DNA, Bacterial
Endopeptidases
Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Bacterial

Genes, Regulator

Phenotype

RNA, Messenger

Restriction Mapping

Streptococcus pyogenes

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 2404953
DOI: 10.1128/jb.172.2.696-700.1990
PMCID: PMC208495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2404953-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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