Article
Mutant BRCA1 alleles transmission: different approaches and different biases.
International journal of cancer - 1 Jan 2005
de la Hoya Miguel, Meijers-Heijboer Hanne, Fernández Juan Manuel, Díez Orland, Osorio Ana, Alonso Carmen, van Leeuwen Inge, Díaz-Rubio Eduardo, Cornelisse Cees, Benítez Javier, Devilee Peter, Caldés Trinidad
Abstract excerpt
Recently, a non-random transmission of BRCA1 mutant alleles to the off-spring of carriers has been suggested. If confirmed by further studies, the finding will have important implications both for risk assessment and the understanding of BRCA1 biology. However, these kind of analysis are not easy to perform due to several ascertainment biases inherent to the identification of BRCA1 carriers. In this report we...
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