Article
Evidence of a founder BRCA1 mutation in Scotland.
British journal of cancer - 1 Feb 2000
Liede A, Cohen B, Black D M, Davidson R H, Renwick A, Hoodfar E, Olopade O I, Micek M, Anderson V, De Mey R, Fordyce A, Warner E, Dann J L, King M C, Weber B, Narod S A, Steel C M
Abstract excerpt
BRCA1 mutations have been identified in breast and ovarian cancer families from diverse ethnic backgrounds. We studied 17 different families with the BRCA1 2800delAA mutation; seven were ascertained in Scotland (Dundee, Edinburgh, Glasgow, St Andrews), five in Canada (Toronto, Victoria) and five in the United States (Chicago, Philadelphia, Seattle). Overall there was a clear preponderance of Scottish ancestry....
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