Bias Explains Most of the Parent-of-Origin Effect on Breast Cancer Risk in BRCA1/2 Mutation Carriers.

doi:10.1158/1055-9965.EPI-16-0182

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Article

Bias Explains Most of the Parent-of-Origin Effect on Breast Cancer Risk in BRCA1/2 Mutation Carriers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2016

Vos Janet R, Oosterwijk Jan C, Aalfs Cora M, Rookus Matti A, Adank Muriel A, van der Hout Annemarie H, van Asperen Christi J, Gómez Garcia Encarna B, Mensenkamp Arjen R, Jager Agnes, Ausems Margreet G E M, Mourits Marian J, de Bock Geertruida H

Abstract excerpt

BACKGROUND: Paternal transmission of a BRCA mutation has been reported to increase the risk of breast cancer in offspring more than when the mutation is maternally inherited. As this effect might be caused by referral bias, the aim of this study was to assess the parent-of-origin effect of the BRCA1/2 mutation on the breast cancer lifetime risk, when adjusted for referral bias. METHODS: A Dutch national cohort...

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PMID: 27277847
DOI: 10.1158/1055-9965.EPI-16-0182

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BRCA1
BRCA2
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