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Article

Mutations and polymorphic BRCA variants transmission in breast cancer familial members.

Breast cancer research and treatment - 1 Feb 2011

Pilato Brunella, Martinucci Marianna, Danza Katia, Pinto Rosamaria, Petriella Daniela, Lacalamita Rosanna, Bruno Michele, Lambo Rossana, D'Amico Cosimo, Paradiso Angelo, Tommasi Stefania

Abstract excerpt

We previously showed that about 80% of breast cancer patients at high risk to carry mutation in BRCA genes presented at least one polymorphism in these genes which resulted potentially harmful by in silico analysis. In the present paper, the genealogic transmission of those polymorphic coding and noncoding variants of BRCA genes in family's members has been investigated. Thirty families, enrolled within the...

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Source

Identifiers

PMID: 20352487
DOI: 10.1007/s10549-010-0861-8

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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