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Article

Single oral dose pharmacokinetics of quazepam is influenced by CYP2C19 activity.

Therapeutic drug monitoring - 1 Oct 2004

Fukasawa Takashi, Yasui-Furukori Norio, Aoshima Toshiaki, Suzuki Akihito, Tateishi Tomonori, Otani Koichi

Abstract excerpt

The effects of cytochrome P450 (CYP)2C19 activity and cigarette smoking on the single oral dose pharmacokinetics of quazepam were studied in 20 healthy Japanese volunteers. Twelve subjects were extensive metabolizers (EMs), and 8 subjects were poor metabolizers (PMs) by CYP2C19 as determined by the PCR-based genotyping. Nine subjects were smokers (>10 cigarettes/d), and 11 subjects were nonsmokers. The subjects...

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Identifiers

PMID: 15385836
DOI: 10.1097/00007691-200410000-00011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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