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Article

Effects of the CYP2C91/13 genotype on the pharmacokinetics of lornoxicam.

Basic & clinical pharmacology & toxicology - 1 Dec 2011

Choi Chang-Ik, Kim Mi-Jeong, Jang Choon-Gon, Park Young-Seo, Bae Jung-Woo, Lee Seok-Yong

Abstract excerpt

Lornoxicam is extensively metabolized by CYP2C9, and a CYP2C9*13 is one of the principal variant alleles in East Asian populations. The aim of this study was to evaluate the effects of CYP2C9*1/*13 on the pharmacokinetic parameters of lornoxicam in healthy individuals. A single oral dose of 8 mg lornoxicam was given to 22 Korean volunteers with different CYP2C9 genotypes (8, 8 and 6 carriers of CYP2C9*1/*1, *1/*3...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase Inhibitors

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Share to Dose-Response Relationship, Drug

Share to Leukocytes, Mononuclear

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Identifiers

PMID: 21726410
DOI: 10.1111/j.1742-7843.2011.00751.x

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