Article
Effects of the CYP2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam.
Progress in neuro-psychopharmacology & biological psychiatry - 1 May 2003
Aoshima Toshiaki, Fukasawa Takashi, Otsuji Yohei, Okuyama Naoyuki, Gerstenberg Gisa, Miura Masatomo, Ohkubo Tadashi, Sugawara Kazunobu, Otani Koichi
Abstract excerpt
The effects of the cytochrome P450 (CYP)2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam were studied in 16 healthy male volunteers. The two mutated alleles (CYP2C19*2 and CYP2C19*3) causing absent CYP2C19 activity were identified by PCR-based restriction enzyme analysis. Five subjects had no mutated allele, five had one mutated allele, and six had two...
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