Article
Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype.
British journal of clinical pharmacology - 1 Jan 2005
Zhang Yifan, Zhong Dafang, Si Dayong, Guo Yingjie, Chen Xiaoyan, Zhou Hui
Abstract excerpt
AIMS: To investigate the pharmacokinetics of lornoxicam and the relationship with CYP2C9 polymorphism in healthy Chinese subjects. METHODS: A single oral dose of 8 mg lornoxicam was administered to 18 healthy Chinese male subjects. Plasma was sampled for 24 h post dose, and plasma concentrations of lornoxicam were measured using a validated LC/MS/MS method. CYP2C9 genotype was determined by polymerase chain...
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