Article
Frequent human leukocyte antigen class I alleles are associated with higher viral load among HIV type 1 seroconverters in Thailand.
Journal of acquired immune deficiency syndromes (1999) - 1 Oct 2004
Nguyen Lily, Chaowanachan Thanyanan, Vanichseni Suphak, McNicholl Janet M, Mock Philip A, Nelson Robert, Hodge Thomas W, van Griensven Frits, Choopanya Kachit, Mastro Timothy D, Tappero Jordan W, Hu Dale J
Abstract excerpt
The loss of viral control by the host may be due to the evolution of viruses with mutations that limit presentation by human leukocyte antigen (HLA) to cytotoxic T cells. The authors hypothesized that the consequence of such evolution might be that persons with common HLA class I alleles would be less able to control viremia, on average, than would those with rare alleles. HLA class I typing was completed for 128...
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