Article
Variation of the factor H-binding protein of Neisseria meningitidis.
Microbiology (Reading, England) - 1 Dec 2009
Brehony Carina, Wilson Daniel J, Maiden Martin C J
Abstract excerpt
There is currently no comprehensive meningococcal vaccine, due to difficulties in immunizing against organisms expressing serogroup B capsules. To address this problem, subcapsular antigens, particularly the outer-membrane proteins (OMPs), are being investigated as candidate vaccine components. If immunogenic, however, such antigens are often antigenically variable, and knowledge of the extent and structuring of...
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