Article
Variation of the factor H-binding protein of Neisseria meningitidis.
Microbiology (Reading, England) - 1 Dec 2009
Brehony Carina, Wilson Daniel J, Maiden Martin C J
Abstract excerpt
There is currently no comprehensive meningococcal vaccine, due to difficulties in immunizing against organisms expressing serogroup B capsules. To address this problem, subcapsular antigens, particularly the outer-membrane proteins (OMPs), are being investigated as candidate vaccine components. If immunogenic, however, such antigens are often antigenically variable, and knowledge of the extent and structuring of...
Topics
- Alleles
- Amino Acid Sequence
- Antigens, Bacterial
- Bacterial Proteins
- Base Sequence
- DNA Primers
- DNA, Bacterial
- Genes, Bacterial
- Genetic Variation
- Humans
- Meningococcal Infections
- Meningococcal Vaccines
- Models, Molecular
- Molecular Sequence Data
- Neisseria meningitidis
- Neisseria meningitidis, Serogroup A
- Neisseria meningitidis, Serogroup B
- Recombination, Genetic