Article
Antigenic diversity of meningococcal enterobactin receptor FetA, a vaccine component.
Microbiology (Reading, England) - 1 Jul 2003
Thompson Emily A L, Feavers Ian M, Maiden Martin C J
Abstract excerpt
Meningococcal FetA (FrpB), an iron-regulated outer-membrane protein and vaccine component, was shown to be highly diverse: a total of 60 fetA alleles, encoding 56 protein sequences, were identified from 107 representative Neisseria meningitidis isolates. Phylogenetic analysis established that the allelic variants had been generated by both point mutation and horizontal genetic exchange. Nucleotide substitution...
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