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Article

Interferon-gamma and interleukin-12 pathway defects and human disease.

Cytokine & growth factor reviews - 1 Dec 2000

Dorman S E, Holland S M

Abstract excerpt

A genetic component to human mycobacterial disease susceptibility has long been postulated. Over the past five years, mutations in the interferon-gamma (IFNgamma) receptor, IL-12 receptor beta1 (IL-12Rbeta1), and IL-12 p40 genes have been recognized. These mutations are associated with heightened susceptibility to disease caused by intracellular pathogens including nontuberculous mycobacteria, vaccine-associated...

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Identifiers

PMID: 10959079
DOI: 10.1016/s1359-6101(00)00010-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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