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Article

Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface.

The Journal of clinical investigation - 1 Jan 2000

Snyder P M

Abstract excerpt

The epithelial Na(+) channel (ENaC) plays a critical role in Na(+) absorption, and mutations in this channel cause diseases of Na(+) homeostasis, including a genetic form of hypertension (Liddle's syndrome). To investigate cAMP-mediated stimulation of ENaC, alpha, beta, and gammaENaC were coexpressed in Fischer rat thyroid epithelia to generate apical Na(+) channels and transepithelial Na(+) current. cAMP...

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Identifiers

PMID: 10619860
DOI: 10.1172/JCI7869
PMCID: PMC382584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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