Article
Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2008
Czuczman Myron S, Olejniczak Scott, Gowda Aruna, Kotowski Adam, Binder Arvinder, Kaur Harman, Knight Joy, Starostik Petr, Deans Julie, Hernandez-Ilizaliturri Francisco J
Abstract excerpt
Acquirement of resistance to rituximab has been observed in lymphoma patients. To define mechanisms associated with rituximab resistance, we developed various rituximab-resistant cell lines (RRCL) and studied changes in CD20 expression/structure, lipid raft domain (LRD) reorganization, calcium mo...
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