Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis.

doi:10.1016/j.jaci.2011.10.026

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Article

Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis.

The Journal of allergy and clinical immunology - 1 Mar 2012

Cabral-Marques Otavio, Arslanian Christina, Ramos Rodrigo Nalio, Morato Mariana, Schimke Lenafriederike, Soeiro Pereira Paulo Vitor, Jancar Sonia, Ferreira Janaíra Fernandes, Weber Cristina Worm, Kuntze Gisele, Rosario-Filho Nelson Augusto, Costa Carvalho Beatriz Tavares, Bergami-Santos Patricia Cruz, Hackett Mary J, Ochs Hans D, Torgerson Troy R, Barbuto Jose Alexandre Marzagão, Condino-Neto Antonio

Abstract excerpt

BACKGROUND: Patients with X-linked hyper-IgM syndrome (X-HIGM) due to CD40 ligand (CD40L) mutations are susceptible to fungal pathogens; however, the underlying susceptibility mechanisms remain poorly understood. OBJECTIVE: To determine whether monocyte-derived dendritic cells (DCs) from patients with X-HIGM exhibit normal responses to fungal pathogens. METHODS: DCs from patients and controls were evaluated for...

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PMID: 22154528
DOI: 10.1016/j.jaci.2011.10.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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