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Article

Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.

Genes & development - 15 Feb 2004

Lin Jue, Blackburn Elizabeth H

Abstract excerpt

Human TRF1-binding protein PinX1 inhibits telomerase activity. Here we report that overexpression of yeast PinX1p (yPinX1p) results in shortened telomeres and decreased in vitro telomerase activity. yPinX1p coimmunoprecipitated with yeast telomerase protein Est2p even in cells lacking the telomerase RNA TLC1, or the telomerase-associated proteins Est1p and Est3p. Est2p regions required for binding to yPinX1p or...

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Identifiers

PMID: 14977919
DOI: 10.1101/gad.1171804
PMCID: PMC359393

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Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.PMID 14977919Read ↗

Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTRSemantic proximity Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual RolesSemantic proximity Read ↗

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer CellsSemantic proximity Read ↗

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read ↗

Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.Semantic proximity Read ↗

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenanceSemantic proximity Read ↗

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Telomerase Interaction Partners–Insight from PlantsSemantic proximity Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

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