Article
Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys.
Aging cell - 1 Oct 2004
Gokey Nolan G, Cao Zhengjin, Pak Jeong W, Lee Damian, McKiernan Susan H, McKenzie Debbie, Weindruch Richard, Aiken Judd M
Abstract excerpt
Mitochondrial DNA (mtDNA) deletion mutations co-localize with electron transport system (ETS) abnormalities in rhesus monkey skeletal muscle fibers. Using laser capture microdissection in conjunction with PCR and DNA sequence analysis, mitochondrial genomes from single sections of ETS abnormal fibers were characterized. All ETS abnormal fibers contained mtDNA deletion mutations. Deletions were large, removing...
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