Article
Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease.
Cell - 13 Jul 1990
Shoubridge E A, Karpati G, Hastings K E
Abstract excerpt
We mapped the distribution and expression of wild-type and deleted mitochondrial DNA (mtDNA) molecules in skeletal muscle fibers of patients with mitochondrial disease. We show that ragged red fiber segments, which are characteristic histological features of these myopathies, represent focal accumulations of mitochondria containing predominantly deleted mtDNAs and that the mutant genomes are absent or extremely...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.